Building Proteins from Amino Acid ChainsWe already showed you some information about amino acids. Proteins are made of amino acids. Even though a protein can be very complex, it is basically a long chain of amino acid subunits all twisted around like a knot.
As proteins are being built, they begin as a straight chain of amino acids. This chain structure is called the primary structure. Sometimes chains can bond to each other with two sulfur (S) atoms. Those bonds would be called a disulfide bridge.
After the primary structure comes the secondary structure. The original chain begins to twist. It's as if you take a piece of string and twist one end. It slowly begins to curl up. In the amino acid chain, each of the amino acids interacts with the others and it twists like a corkscrew (alpha helix) or it takes the shape of a folded sheet (beta sheet). We talked about amino acids that are hydrophobic and hydrophilic. Those desires to stay away or be close to water (H2O) play a part in the twisting.
Tertiary Makes Step Three
Let's move on to the tertiary structure of proteins. By now you're probably getting the idea that proteins do a lot of folding and twisting. The third step in the creation of a protein is the tertiary structur. The amino acid chains begin to fold even more and bond using more bridges (the disulfide bridges).
Quaternary Is Fourth and Final
We can finally cover the quaternary structure of proteins. Quaternary means four. This is the fourth phase in the creation of a protein. In the quaternary structure, several amino acid chains fromthe tertiary structures fold together in a blob. You heard us right. "Blob" is the term we use on this site. They wind, entwined, in and out of each other. Some of the most famous protein blobs are hemoglobin in human red blood cells and the photosystems in plant chloroplasts.
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- Nucleic Acids
- Amino Acids
- 20 Amino Acids
- Enz. Regulation
- More Topics
3D Proteins: The Big Picture (US-NSF Video)
Source: Angewandte Chemie/Wiley
Useful Reference MaterialsEncyclopedia.com:
Books on Amazon.com:
- Prentice Hall Chemistry (Wilbraham)
- Principles of Biochemistry (Nelson and Cox)
- Chemistry: The Molecular Nature of Matter and Change (Silberberg)
- Fundamentals of Biochemistry (Voet)
- Biochemistry Books